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1

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs

Appendino, Giovanni, Minassi, Alberto, Taglialatela-Scafati, Orazio

Journal:

Natural Product Reports

Year:

2014

Language:

english

File:

PDF, 689 KB

english, 2014

2

Cannabichromene

Pollastro, Federica, Caprioglio, Diego, Del Prete, Danilo, Rogati, Federica, Minassi, Alberto, Taglialatela-Scafati, Orazio, Munoz, Eduardo, Appendino, Giovanni

Journal:

Natural Product Communications

Year:

2018

Language:

english

File:

PDF, 435 KB

english, 2018

3

Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter

Orazio Taglialatela-Scafati, Federica Pollastro, Alberto Minassi, Giuseppina Chianese, Luciano De Petrocellis, Vincenzo Di Marzo, Giovanni Appendino

Journal:

European Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 530 KB

english, 2012

4

The Oxidation of Phytocannabinoids to Cannabinoquinoids

Caprioglio, Diego, Mattoteia, Daiana, Pollastro, Federica, Negri, Roberto, Lopatriello, Annalisa, Chianese, Giuseppina, Minassi, Alberto, Collado, Juan A., Munoz, Eduardo, Taglialatela-Scafati, Orazio

Journal:

Journal of Natural Products

Year:

2020

File:

PDF, 1014 KB

2020

5

Pietro Biginelli: The Man Behind the Reaction

Gian Cesare Tron, Alberto Minassi, Giovanni Appendino

Journal:

European Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

6

Hot Cuisine as a Source of Anti-Inflammatory Drugs

Giovanni Appendino, Alberto Minassi, Nives Daddario

Journal:

Phytochemistry Reviews

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

7

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation

Nieves Márquez, Marco A. Calzado, Gonzalo Sánchez-Duffhues, Moisés Pérez, Alberto Minassi, Alberto Pagani, Giovanni Appendino, Laura Diaz, Maria Ángeles Muñoz-Fernández, Eduardo Muñoz

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.02 MB

english, 2008

8

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

Tiziana Bisogno, Maria Grazia Cascio, Bijali Saha, Anu Mahadevan, Paolo Urbani, Alberto Minassi, Giovanni Appendino, Carmela Saturnino, Billy Martin, Raj Razdan, Vincenzo Di Marzo

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2006

Language:

english

File:

PDF, 241 KB

english, 2006

9

Antimicrobial Phenolics and Unusual Glycerides from Helichrysum italicum subsp. microphyllum

Taglialatela-Scafati, Orazio, Pollastro, Federica, Chianese, Giuseppina, Minassi, Alberto, Gibbons, Simon, Arunotayanun, Warunya, Mabebie, Blessing, Ballero, Mauro, Appendino, Giovanni

Journal:

Journal of Natural Products

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

10

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space

Lopatriello, Annalisa, Caprioglio, Diego, Minassi, Alberto, Schiano Moriello, Aniello, Formisano, Carmen, De Petrocellis, Luciano, Appendino, Giovanni, Taglialatela-Scafati, Orazio

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 650 KB

english, 2018

11

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity

Rogati, Federica, Millán, Estrella, Appendino, Giovanni, Correa, Alejandro, Caprioglio, Diego, Minassi, Alberto, Muñoz, Eduardo

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 1.59 MB

english, 2019

12

Three-Component Tandem Knoevenagel/Hetero Diels−Alder Reactions − Total Synthesis of (±)-Preethulia Coumarin

Giovanni Appendino, Giancarlo Cravotto, Alberto Minassi, Giovanni Palmisano

Journal:

European Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 325 KB

english, 2001

13

Synthesis and Evaluation of 14-Nor-A-secotaxoids

Giovanni Appendino, Emanuela Belloro, Erika Del Grosso, Alberto Minassi, Ezio Bombardelli

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 351 KB

english, 2002

14

Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-κB activation and is a potent antiinflammatory compound in vivo

Rocío Sancho, Concepción Lucena, Antonio Macho, Marco A. Calzado, Magdalena Blanco-Molina, Alberto Minassi, Giovanni Appendino, Eduardo Muñoz

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 341 KB

english, 2002

15

The 1,2,3-Triazole Ring as a Peptido- and Olefinomimetic Element: Discovery of Click Vanilloids and Cannabinoids

Giovanni Appendino, Sara Bacchiega, Alberto Minassi, Maria Grazia Cascio, Luciano De Petrocellis, Vincenzo Di Marzo

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 386 KB

english, 2007

16

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Dr. Cristina Avonto, Prof. Orazio Taglialatela-Scafati, Dr. Federica Pollastro, Prof. Alberto Minassi, Prof. Vincenzo Di Marzo, Dr. Luciano De Petrocellis, Prof. Giovanni Appendino

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 339 KB

english, 2011

17

The 1,2,3-Triazole Ring as a Peptido- and Olefinomimetic Element: Discovery of Click Vanilloids and Cannabinoids

Giovanni Appendino, Sara Bacchiega, Alberto Minassi, Maria Grazia Cascio, Luciano De Petrocellis, Vincenzo Di Marzo

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 386 KB

english, 2007

18

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Dr. Cristina Avonto, Prof. Orazio Taglialatela-Scafati, Dr. Federica Pollastro, Prof. Alberto Minassi, Prof. Vincenzo Di Marzo, Dr. Luciano De Petrocellis, Prof. Giovanni Appendino

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 328 KB

english, 2011

19

ChemInform Abstract: Synthesis of Esters from Silyl Ethers and Acyl Chlorides: Catalysis by Quaternary Ammonium Chlorides.

S. BRANDAENGE, H. LEIJONMARCK, T. MINASSIE

Journal:

Year:

1997

File:

PDF, 29 KB

1997

20

Chemoselective Esterification of Phenolic Acids and Alcohols.

Giovanni Appendino, Alberto Minassi, Nives Daddario, Federica Bianchi, Gian Cesare Tron

Journal:

Year:

2003

File:

PDF, 136 KB

2003

21

Cerium(III) Chloride Promoted Chemoselective Esterification of Phenolic Alcohols.

Elisabetta Torregiani, Gianfranco Seu, Alberto Minassi, Giovanni Appendino

Journal:

Year:

2005

File:

PDF, 25 KB

2005

22

An Expeditious Hydroxyamidation of Carboxylic Acids.

Abdellah Ech-Chahad, Alberto Minassi, Luca Berton, Giovanni Appendino

Journal:

Year:

2005

File:

PDF, 20 KB

2005

23

ChemInform Abstract: A Multicomponent Synthesis of gem-(β-Dicarbonyl)arylmethanes

Giovanni Appendino, Lavinia Cicione, Alberto Minassi

Journal:

Year:

2010

File:

PDF, 28 KB

2010

24

ChemInform Abstract: Tandem β-Alkylation—α-Arylation of Amines by Carbolithiation and Rearrangement of N-Carbamoyl Enamines (Vinyl Ureas).

Jonathan Clayden, Morgan Donnard, Julien Lefranc, Alberto Minassi, Daniel J. Teltow

Journal:

Year:

2010

File:

PDF, 57 KB

2010

25

ChemInform Abstract: Geometry-Selective Synthesis of (E) or (Z) N-Vinyl Ureas (N-Carbamoyl Enamines).

Julien Lefranc, Daniel J. Tetlow, Morgan Donnard, Alberto Minassi, Erik Galvez, Jonathan Clayden

Journal:

Year:

2011

File:

PDF, 61 KB

2011

26

ChemInform Abstract: Pietro Biginelli: The Man Behind the Reaction.

Gian Cesare Tron, Alberto Minassi, Giovanni Appendino

Journal:

Year:

2012

File:

PDF, 18 KB

2012

27

Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids

Giovanni Appendino, Andrea Bertolino, Alberto Minassi, Rita Annunziata, Arpad Szallasi, Luciano de Petrocellis, Vincenzo Di Marzo

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 168 KB

english, 2004

28

Cover Picture: Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids (Eur. J. Org. Chem. 16/2004)

Giovanni Appendino, Andrea Bertolino, Alberto Minassi, Rita Annunziata, Arpad Szallasi, Luciano de Petrocellis, Vincenzo Di Marzo

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 53 KB

english, 2004

29

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers – Total Synthesis and Structure–Activity Relationships of Arzanol

Alberto Minassi, Lavinia Cicione, Andreas Koeberle, Julia Bauer, Stefan Laufer, Oliver Werz, Giovanni Appendino

Journal:

European Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 405 KB

english, 2012

30

Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety

Giovanni Appendino, Abdellah Ech-Chahad, Alberto Minassi, Sara Bacchiega, Luciano De Petrocellis, Vincenzo Di Marzo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

31

Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene

Giovanni Appendino, Abdellah Ech-Chahad, Alberto Minassi, Luciano De Petrocellis, Vincenzo Di Marzo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 236 KB

english, 2010

32

Roasting impact on the contents of clovamide (N-caffeoyl-L-DOPA) and the antioxidant activity of cocoa beans (Theobroma cacao L.)

Marco Arlorio, Monica Locatelli, Fabiano Travaglia, Jean-Daniel Coïsson, Erika Del Grosso, Alberto Minassi, Giovanni Appendino, Aldo Martelli

Journal:

Year:

2008

Language:

english

File:

PDF, 187 KB

english, 2008

33

Cerium(III) chloride-promoted chemoselective esterification of phenolic alcohols

Elisabetta Torregiani, Gianfranco Seu, Alberto Minassi, Giovanni Appendino

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

34

An expeditious hydroxyamidation of carboxylic acids

Abdellah Ech-Chahad, Alberto Minassi, Luca Berton, Giovanni Appendino

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 95 KB

english, 2005

35

A multicomponent synthesis of gem-(β-dicarbonyl)arylmethanes

Giovanni Appendino, Lavinia Cicione, Alberto Minassi

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 329 KB

english, 2009

36

Non-pungent capsaicinoids from sweet pepper

Antonio Macho, Concepción Lucena, Rocio Sancho, Nives Daddario, Alberto Minassi, Eduardo Muñoz, Giovanni Appendino

Journal:

European Journal of Nutrition

Year:

2003

Language:

english

File:

PDF, 353 KB

english, 2003

37

Umbellulone modulates TRP channels

Jian Zhong, Alberto Minassi, Jean Prenen, Orazio Taglialatela-Scafati, Giovanni Appendino, Bernd Nilius

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 887 KB

english, 2011

38

Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB1 receptors

Giovanni Appendino, Alessia Ligresti, Alberto Minassi, Nives Daddario, Tiziana Bisogno, Vincenzo Di Marzo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

39

Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death

S Fallarini, G Miglio, T Paoletti, A Minassi, A Amoruso, C Bardelli, S Brunelleschi, G Lombardi

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 354 KB

english, 2009

40

Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

Appendino, Giovanni, Ligresti, Alessia, Minassi, Alberto, Cascio, Maria Grazia, Allarà, Marco, Taglialatela-Scafati, Orazio, Pertwee, Roger G., De Petrocellis, Luciano, Di Marzo, Vincenzo

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 189 KB

english, 2009

41

Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)

Appendino, Giovanni, Bianchi, Federica, Minassi, Alberto, Sterner, Olov, Ballero, Mauro, Gibbons, Simon

Journal:

Journal of Natural Products

Year:

2002

Language:

english

File:

PDF, 61 KB

english, 2002

42

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

Cassia R. Overk, Jian Guo, Lucas R. Chadwick, Daniel D. Lantvit, Alberto Minassi, Giovanni Appendino, Shao-Nong Chen, David C. Lankin, Norman R. Farnsworth, Guido F. Pauli, Richard B. van Breemen, Jud

Journal:

Chemico-Biological Interactions

Year:

2008

Language:

english

File:

PDF, 945 KB

english, 2008

43

Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation

Antonella Rosa, Giovanni Appendino, M. Paola Melis, Monica Deiana, Angela Atzeri, Incani Alessandra, Alberto Minassi, M. Assunta Dessì

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

44

Anti-inflammatory and vascularprotective properties of 8-prenylapigenin

Tiziana Paoletti, Silvia Fallarini, Francesca Gugliesi, Alberto Minassi, Giovanni Appendino, Grazia Lombardi

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 989 KB

english, 2009

45

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Elisa Brunelli, Giulia Pinton, Paolo Bellini, Alberto Minassi, Giovanni Appendino, Laura Moro

Journal:

Year:

2009

Language:

english

File:

PDF, 874 KB

english, 2009

46

Protective activation of the endocannabinoid system during ischemia in dopamine neurons

Miriam Melis, Giuliano Pillolla, Tiziana Bisogno, Alberto Minassi, Stefania Petrosino, Simona Perra, Anna Lisa Muntoni, Beat Lutz, Gian Luigi Gessa, Giovanni Marsicano, Vincenzo Di Marzo, Marco Pistis

Journal:

Neurobiology of Disease

Year:

2006

Language:

english

File:

PDF, 562 KB

english, 2006

47

A structure–activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase

Maria Grazia Cascio, Alberto Minassi, Alessia Ligresti, Giovanni Appendino, Sumner Burstein, Vincenzo Di Marzo

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 138 KB

english, 2004

48

First “hybrid” ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

Giovanni Appendino, Maria Grazia Cascio, Sara Bacchiega, Aniello Schiano Moriello, Alberto Minassi, Adèle Thomas, Ruth Ross, Roger Pertwee, Luciano De Petrocellis, Vincenzo Di Marzo

Journal:

Year:

2006

Language:

english

File:

PDF, 157 KB

english, 2006

49

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine

Sherry Shu-Jung Hu, Heather B. Bradshaw, Valery M. Benton, Jay Shih-Chieh Chen, Susan M. Huang, Alberto Minassi, Tiziana Bisogno, Kim Masuda, Bo Tan, Robert Roskoski Jr., Benjamin F. Cravatt, Vincenzo

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2009

Language:

english

File:

PDF, 402 KB

english, 2009

50

Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues

Filomena Fezza, Tiziana Bisogno, Alberto Minassi, Giovanni Appendino, Raphael Mechoulam, Vincenzo Di Marzo

Journal:

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

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